Sinobioway Group Co., Ltd.

[Drug name]

Recombinant Human Erythropoietin Injection (CHO cell)

Trademark: Yebo

[Pharmacological action]

This product is made from Chinese hamster ovary (CHO) cells which express human erythropoietin gene, which is highly expressed by cells, cultured, isolated and highly purified. Erythropoietin is a kind of active glycoprotein secreted by the kidney, which can promote the proliferation and differentiation of hematopoietic progenitor cells in the bone marrow. This product can significantly improve the hemoglobin content and red blood cell count.

[Indications]

1. Anemia caused by renal insufficiency, including chronic renal failure, hemodialysis and non dialysis treatment;

2, Non bone marrow malignant tumor patients with chemotherapy related anemia;

[Taboo]

Allergy to this product or similar preparations and other preparations for the expression of hamster ovary cells are disabled.

[Adverse Reactions]

Patients using this product after the main adverse reaction for headache, fever, fatigue, chest tightness, and individual patient can myalgia and arthralgia. The adverse reactions were mild, easy to tolerate, generally do not need special treatment or symptomatic treatment can improve, do not affect the continued use of drugs.

[Note]

1.During the medication should be regularly check the red cell pressure, pay attention to avoid excessive red blood cell formation (confirm the red cell pressure product in 36vol% below);

2. Application of this product can sometimes cause slight increase in serum potassium, should be appropriate to adjust the diet, if the occurrence of blood potassium increased, should follow the doctor's advice to adjust the dose;

3. For patients with myocardial infarction, pulmonary infarction, cerebral infarction, patients with a history of drug allergy and allergic patients should be carefully given drug;

4. During the period of treatment. Due to the emergence of the effective hematopoietic, increased demand for iron, usually decreased serum iron concentration, if serum ferritin in patients with lower than 100ng / ml, or transferrin saturation below 20%, daily iron supplement;

5. Folic acid or vitamin B12 deficiency will reduce the efficacy of this product. Too much aluminum will also affect the effectiveness of this product.