Sinobioway Group Co., Ltd.

[Drug name]

Generic name: recombinant human interferon alpha 2b, glass prefillable syringe

Brand name: ANFERON, glass prefillable syringe

[Indication]

ANFERON is indicated in adult for the treatment of the following diseases: acute or chronic viral hepatitis(Type B, Type C, etc.), Condylomata acuminata, hairy cell leuke, chronic myelogenous, leukemia, lymphomas, AIDS related Kaposi's sarcoma malignant melanoma etc.

[Administration and dosage]

ANFERON is administrated in intramuscular, subcutaneous or intratumoral injection.

1. Chronic viral hepatitis(Type B)

The recommended dosage of ANFERON is 3-5 million IU administered once daily or every other day. The physician may adjust dosage according to patient's response and tolerance to medication.

2. Chronic viral hepatitis(Type C)

The recommended dosage of ANFERON is 3-5 million IU administered once daily or every other day. The physician may adjust dosage according to patient's response and tolerance to medication.

3. Condylomata acuminata

The recommended dosage of ANFERON is 1-3 million IU administered three times a week (every other day). The course of treatment is 1-2 months.

4. Hairy cell leukemia

The recommended dosage of ANFERON is 3 million IU administered three times a week (every other day).

The physician may adjust dosage according to patient's response and tolerance to medication. The response is achieved usually after 1-2 months of treatment. Long-term palliation may be achieved by intermittent treatment of ANFERON.

5. Chronic myelogenous leukemia

The recommended dosage of ANFERON is 3-9 million IU administered daily for 3 months. The physician may adjust dosage acording to patient's response and tolerance to medication. All patients with complete hemetologic response should continue injeciton every other day. the cytogenetic changes may be achieved in 9-10 months.

6. Lymphoma(Follicular lymphorma)

The recommended dosage of ANFERON is 3 million IU administered three times a week (every other day). The physician may gradually increase dosage according to patient's response and tolerance to medication until reach the maxium dosage of 9-18 million IU three times a week(every other day) for 8-12 weeks. The treatment should be maintained for 12 months unless disease progresses rapidly or severe intolerance occurs. The physician may adjust dosage according to patient's response and tolerance to medication and combine with photochemical therapeutics.

7. AIDS related Kaposi's Sarcoma

The recommended dosage of ANFERON is 18 million IU administered daily. To gradually increase the dosage to 36 million IU and maintain the treatment unless disease progressess rapidly or severe intolerance manifested. Adjust the dosage to 18 million IU(three times a week) when the reaction is steady.

8. Malignant melanoma

The recommended dosage of ANFERON is 9-18 million IU administered three times a week (every other day) until the effective response achieved. Dosage may be adjust according to patient's response and tolerance to medication by the physician.This maintenance regimen could be used to decrease the recurrence after surgical removal of stage I-II malignant melanoma.